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These bacteria are responsible of the death of MRD appeared because they have developed resistance against antibiotics, mainly because of the bad habit we have on them, and they are extremely dangerous. Luckily, virus could help us to beat them. Specifically, the ones called bacteriophages. I join you to find out how. The WHO has published a list of those for which an immediate antibiotic is required.

In view of not having it in a short term, what other option do we suggest? Pseudomonas, Staphylococcus aerus, Escherichia coli, Enterococcus faecium, Streptococcus pneumoniae, Aeromonas hidrofila, Mycobacterium tuberculosis, among other, are the names of the bacteria which are being found multiresistant population that mock the action of antibiotics. We have in our hands the possibility of beat them, giving our trust to the use of bacteriophages, coming out the Phage Therapy.

This treatment consists in the use of bacteriophages phage as bactericide. This phages have a high specificity: they can infect one or a few strains of a bacterial species, so they are not only harmless against eukaryotic cells but also for our microbiota, so Phage Therapy would not harm the treated person.

Electronic micrograph of bacteriophages, the viruses that Phage Therapy would use, adhering and infecting a bacterium. Source: wikipedia. How Phage Therapy acts? When the phage is supplied, it establishes a highly specific recognition against certain receptors on the surface of the bacterium, with which it interacts and adheres to its surface. After this, the phage enters its genetic material inside the bacteria. In the lytic cycle, the phage takes advantage of the bacteria own resources to produce the synthesis of mRNA necessary to generate copies of the capsid, viral nucleic acids and viral enzymes that will help to lyse the bacteria and kill it.

So that, from a single phage, hundreds of them are generated inside the bacteria, which leave the host once their components are assembled, destroying it. Lytic cycle of a bacteriophage against an enterobacteria. In addition, phages can reach sites that antibiotics cannot, and can be used as a preventive treatment. Another advantage of phages is that their production is much faster than antibiotics, since it is much easier to select new phages than to find a new antibiotic.

Despite the advantages, there are also problems in Phage Therapy, which delay their commercial use. Among them we find the following, many of which we will see that have been found a solution: Some bacteria develop phage resistance through various systems. The main one consists in the mutation of the receptors that phages use as a recognition element.

To solve this problem, it is counterattacked with a cocktail of phages with different mechanisms of infection, which ensure that, although the bacterium generates resistance to infection, it does not do so against all phages. The next problem is at the regulatory level. There is also difficulty registering them as intellectual property. Another difficulty lies in the release of endotoxins by certain bacteria when they are lysed which can harm the patient.

To solve it, Anakiraman Ramachandran, president of the Canadian biotechnology company GangaGen, proposes to use genetically modified phages. The modification consists on the elimination of the gene responsible for producing endolysins , hydrolytic enzymes responsible for the destruction of the bacterial membrane that allows the release of the new phages.

And thereby could gain access to a huge market of cell phone owners who do not have GPS. Currently it is working with an array of teleservice providers. It has also tied up with a number of shopping malls, enabling the shops to advertise and lure customers.

Alongside, it is also trying to push forward the concept of automatic toll payments. Apart from these Imere has something very interesting up its sleeve-- automatic check-in at airports to passengers through its application. Founder: Anil Mathews Investors: Rediff. The company has not signed any patent as they believe their product is that of a standard software. For them their competition is with the big players like Wipro.

But in later stages, they aim to diversify by aiming the mid-players, rather than high-end hospital industry. Hence their clients are generally from outside metros. By virtue of the sector the company is in and its innovative offering could make it big in the next five years.

Invention Labs is working on manufacturing low-cost products that would help improve the quality of life of these people. Started by alumni of IIT-Madras, Invention Labs has developed AVAZ, a low-cost hand-held device that helps people with cerebral palsy communicate and express their needs, much like the one made famous by Stephen Hawking. The device is fairly affordable at Rs 30, The innovators have filed for a patent for their innovation.

Or say have a laid-back Sunday, brunching with the kangaroos? Or better, how about reviving the writer in you by booking yourself for an Angels and Demons tour? You wonder where this is leading to? Well, to Isango. Launched in , Isango combines holiday travel with more engaging and uniquely experiential activties to provide a more wholesome package to customers through its online reservation service.

It offers a gamut of activities ranging from flamenco dancing in Madrid to the Eiffel Tower restaurant dinner besides offering holidays and sight-seeing across 65 countries to independent travellers. Currently, its focus is more on Europe and it plans to expand its portfolio of activities in America and India.

Top line: N. URL: www. Agarwal and R. With a vision of combining the age old wisdom of Ayurveda with modern manufacturing techniques for creating winning brands, the company was started with a meager amount of Rs 20, Agarwal speaks to DARE about his entrepreneurial journey This has always been my driving mantra. Since my youth I have never been averse to take risks. Then why did you decide to start your own business? Though I was in a high profile job, being a president of the company under the legendary Late Aditya Birla, the fact remained that business was in my blood as I belonged to a business family.

My family was in the business of dyes and colors. It was a considerably large business though later, for various reasons, my family could not sustain it. So driven by the spirit of entrepreneurship, I decided to take a plunge in business. Despite the fact that I had the honor and privilege to work under Late Shri Aditya Birla, I felt like doing something on my own and establish myself as a businessman.

Y Honestly, how long did it take between the initial thought of your own business to actually quitting your job and starting the business? Can you share with us the thoughts that were coming to your mind and how you dealt with them? I had the thought of venturing into business while I was in service. Frankly, taking a trip down the memory lane at this juncture and recalling when exactly I decided to shift to my own enterprise will be very difficult.

But it was always on my mind and I was waiting for the right opportunity to make an entry. It was also a very conscious decision to enter the cosmetics business. Since I am a great believer in the holistic healing of ayurveda, my intention was to base our products on ayurvedic formulations.

I also felt that the market for the ayurveda-driven personal and healthcare products is immense in India and there is a huge scope to exploit this opportunity. We did not want to emulate the MNCs but do something that is linked with our cultural ethos. Was it Friendship, relationship, money or skill sets— what did you both see in each other to start this business together? I knew RS Goenka from my school days. We used to study together at Maheshwari Vidyalaya. I was a year senior to him.

We gelled very well and I also used to tutor him on different subjects as I was very good in studies. We do not consider ourselves as separate entities. We are the opposite sides of the same coin. Theoritically, it is Agarwal and Goenka family.

But, in reality it is one unit. The bond between us is seamless and natural. I also feel that we have been able to stay together because both of us are givers and not takers. Both RS Goenka and myself want the other to do well. How did you spot an opportunity for this business? Why did you decide to go ahead with this business?

I always thought of venturing into the FMCG business—in the manufacture of personal and healthcare products for I felt that the scope in this segment is enormous. Besides, this is also one segment which has no government regulation. So it was a very well thought out decision to venture into the FMCG sector.

From an assured monthly salary to going out on the streets to make business—please tell us about the emotions, feelings, practical challenges that you faced during this transition? No risk, no gain. Since my youth I was never averse to take risks. And as mentioned earlier I was determined to do business. But there was resistance from my family during the initial days. Everybody was very apprehensive. There was the fear in them about the risk involved in any commercial enterprise.

Since I was working in the rank of a President, before moving on to the business, my family members led a very comfortable life. It was scary for them to break out from the then comfort zone and usher in a life of uncertainty and risk. Frankly, it is the conviction of my courage that got me going. What were the biggest challenges that you faced as an aspiring entrepreneur — personal, professional and financial? Finance was definitely a problem. I did not have enough funds to start a business.

That is how the journey began. Since I was already exposed to the nittygritty of the business by being in service earlier, I could understand the nuances of our business quickly. RS Goenka and I supplemented each other. Besides, my knowledge as a CA and CS had also been of great help. Looking back at your entrepreneurial journey, what would you say has been the biggest success as an entrepreneur?

The feeling of each success story is overwhelmingly different from the other. Moreover, I have many plans for the future and I aspire to taste more success in the coming days. Who knows the joy of those might surpass the feelings of all my previous success stories. That is how the journey began What is the one failure that you would say you learnt a lot from? I do not want to remember my failures. I do not want to glorify them. Let me say that failure is not defeat unless you stop trying to achieve it.

Just a couple of years back, you ventured into realty. What are your plans there? In the realty sector we have several projects in hand with more than million sq ft currently under construction. Besides, post acquisition of Zandu Pharmaceutical Works, we plan to develop a 2.

In the field of FMCG, what would you say are the areas that hold good potential for aspiring entrepreneurs? I would say non-durable products of mass consumption have a very good prospect in India. When did you know that it was time for you to go behind the scene and hand over operations to the professionals? Let me clarify that I do not act from behind the curtain. I lead from the front despite my indifferent health. My hands are full and we intend to become a Rs - Rs 10, crore company over the next five years.

So for me the question of going behind the scene does not arise. So the responsibility has already been handed over to the professionals and RS Goenka and myself oversee their functions. Have you trained the next generation of the family to take over? What are their roles going to be? The next generation directors have already been groomed up and are discharging their duties very effectively. In this context I would like to say that the recent acquisition of Zandu has been spearheaded by our next generation directors only.

Who were the biggest pillars of support in your early struggling days? My friend and co-founder of Emami, RS Goenka and his family have been my biggest support during the initial days of struggle. Besides, there has been great support from friends and associates.

I would also like to mention that Bhagwat Gita has always greatly influenced my life and living. It has always been a great source of courage and provided enormous mental support during difficult times. Who were your biggest critics? How did you deal with them? Fortunately, I had a lot of admirers but no critics. All wished me well. How much personal time did you get when you started business? Needless to say, during the initial days there was hardly any time for me to spare for my family.

How much time do you get now?

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